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Updated: Aug 8, 2025

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MicroRNAs in POI, DOR and POR

Jiali Luo1,2, Zhaogui Sun3

  • 1NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Medical School, Fudan University, Shanghai, China.

Archives of Gynecology and Obstetrics
|February 25, 2023
PubMed
Abstract

Insights

MicroRNAs (miRNAs) play key roles in premature ovarian insufficiency (POI), diminished ovarian reserve (DOR), and poor ovarian response (POR). Exosomal miRNAs show therapeutic potential for restoring ovarian function, offering new diagnostic and treatment strategies.

Area of Science:

  • Reproductive Biology
  • Molecular Endocrinology
  • Genetics

Background:

  • Premature ovarian insufficiency (POI) affects ovarian activity before age 40, with unknown etiology in most cases.
  • Diminished ovarian reserve (DOR) and poor ovarian response (POR) are clinically related conditions to POI.
  • MicroRNAs (miRNAs) are increasingly recognized for their involvement in reproductive health.

Purpose of the Study:

  • To review the role of miRNAs in the pathogenesis of POI, DOR, and POR.
  • To evaluate the therapeutic potential of miRNAs for these ovarian conditions.
  • To explore miRNAs as diagnostic and predictive biomarkers.

Main Methods:

  • Comprehensive literature search across six major scientific databases.
  • Analysis of expression profiles and functional studies of miRNAs in human and animal models of ovarian insufficiency.
  • Review of studies on circulating miRNAs and exosome-mediated miRNA delivery.

Main Results:

  • miRNAs regulate key ovarian functions including steroidogenesis, granulosa cell proliferation, apoptosis, and follicular development via specific signaling pathways.
  • Differentially expressed circulating miRNAs, such as miR-22-3p and miR-21, show promise as diagnostic biomarkers.
  • Stem cell-derived exosomes carrying miRNAs demonstrated restoration of ovarian function in chemotherapy-induced POI models.

Conclusions:

  • miRNA expression profiles elucidate mechanisms and identify biomarkers for ovarian insufficiency.
  • Exosomal miRNAs offer a promising avenue for restoring ovarian function, particularly in chemotherapy-induced POI.
  • Further research is needed to translate these findings into clinical preventive and therapeutic strategies.
Keywords:
Diminished ovarian reserveExosomePoor ovarian responsePremature ovarian insufficiencymicroRNAs

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