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Updated: Aug 8, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Choosing Wisely internationally - helpful recommendations for antimicrobial stewardship!
Norma Jung1, Lukas Tometten2, Rika Draenert3
1Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Faculty of Medicine, University Clinics, Cologne, Germany. norma.jung@uk-koeln.de.
Antimicrobial stewardship (AMS) is crucial for combating resistance. Choosing Wisely campaigns globally highlight key areas like indication and diagnostics, emphasizing avoiding unnecessary antibiotic use for common infections.
Area of Science:
- Global Health
- Infectious Diseases
- Pharmacology
Background:
- Antimicrobial resistance (AMR) is a significant global health threat.
- Antibiotic overuse is a primary driver of AMR.
- Antimicrobial stewardship (AMS) aims to optimize antibiotic use.
Purpose of the Study:
- To review Choosing Wisely recommendations related to AMS practices.
- To identify common themes and future needs in AMS.
- To analyze recommendations from selected countries.
Main Methods:
- Evaluated Choosing Wisely recommendations from six countries (Australia/New Zealand, Canada, Italy, Switzerland, USA, Germany).
- Focused on recommendations pertaining to diagnostics, indication, drug choice, dosing, application, and duration of therapy.
- Categorized 213 extracted recommendations.
Main Results:
- No recommendations were found for antibiotic dosing.
- Indication (85) and diagnostics (78) were the most frequent recommendation categories.
- Avoiding treatment for asymptomatic bacteriuria and upper respiratory tract infections were common themes.
Conclusions:
- Choosing Wisely recommendations frequently address AMS, a vital strategy against AMR.
- Selected countries prioritize similar AMS issues.
- Further research may be needed to address antibiotic dosing recommendations.
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