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Updated: Aug 8, 2025

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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Circulating HPV DNA in HPV-associated cancers.

Guigao Lin1, Jinming Li1

  • 1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, PR China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 25, 2023
PubMed
Summary

Circulating human papillomavirus DNA (cHPV-DNA) shows promise as a biomarker for detecting and monitoring HPV-driven cancers. Further clinical trials are needed to confirm its utility in screening, diagnosis, and treatment across the cancer care continuum.

Keywords:
Circulating tumor DNA (ctDNA)Digital droplet PCR (ddPCR)HPV-associated cancersHuman papillomavirus (HPV)Liquid biopsiesNext-generation sequencing (NGS)

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