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Prostatic Artery Embolization in Patients with Prostate Cancer: A Systematic Review
Orlando Burkhardt1, Dominik Abt2, Daniel Engeler1
1Department of Urology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.
European Urology Focus
|February 25, 2023
Summary
Prostatic artery embolization (PAE) offers functional improvement for lower urinary tract symptoms in prostate cancer patients. However, its oncological benefits remain uncertain due to limited evidence and debatable tumor response.
Area of Science:
- Interventional Radiology
- Urology
- Oncology
Background:
- Prostatic artery embolization (PAE) is a common treatment for benign prostatic obstruction (BPO).
- Its application in prostate cancer (PCa) patients requires further investigation.
- The current literature on PAE for PCa is limited and lacks robust evidence.
Approach:
- A systematic review was conducted following PRISMA guidelines.
- Literature search included Medline, Embase, and York CRD from 1985 to 2022.
- Risk of bias was assessed using the ROBINS tool.
Key Points:
- Thirteen studies (12 case series, 1 animal study) were included.
- Four studies had a prospective design.
- All studies exhibited moderate to serious risk of bias.
Conclusions:
- PAE appears safe and effective for improving LUTS in PCa patients.
- Oncological outcomes are debatable due to unreliable tumor response.
- Further controlled trials with long-term follow-up are necessary to clarify oncological benefits.
