"Lighting up" fluorescence precise recognition of Al³⁺ with an effective fluorescence detection using a Bisphenol...

Area of Science:

• Analytical Chemistry
• Environmental Science
• Biomedical Sensing

Background:

• Aluminum (Al3+) is widespread in the environment, posing significant health risks.
• Accurate and sensitive detection methods for Al3+ are crucial for monitoring its impact.
• Existing methods may lack the required sensitivity, selectivity, or on-site applicability.

Purpose of the Study:

• To develop a novel fluorescent chemosensor for sensitive and selective detection of Al3+.
• To evaluate the sensor's performance in complex media and biological systems.
• To explore practical applications, including smartphone-based detection and bio-imaging.

Main Methods:

• Synthesis of a novel Schiff-base fluorescent chemosensor (BFASA) from bisphenol A and salicylaldehyde.
• Spectroscopic analysis (fluorescence and absorbance) to study metal ion binding.
• Determination of stoichiometry (Job's plot, TOF-MS), detection limit, selectivity, and pH range.
• Application in smartphone-based sensing and fluorescence bio-imaging in living cells.

Main Results:

• BFASA exhibited a 'switch-on' fluorescence response with a color change (colorless to green) upon Al3+ binding.
• High selectivity for Al3+ over other metal ions, with a low detection limit (0.56 μM) and optimal pH range (5-8).
• Successful application in smartphone-based Al3+ detection and effective fluorescence bio-imaging of Al3+ in living cells.

Conclusions:

• The developed BFASA chemosensor offers a rapid, sensitive, and selective method for Al3+ detection.
• Its practical applicability is demonstrated through smartphone integration and bio-imaging capabilities.
• BFASA provides a valuable tool for on-site Al3+ monitoring and understanding its biological effects.