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ILC2s in skin disorders.

Yasutomo Imai1

  • 1Imai Adult and Pediatric Dermatology Clinic, Osaka, Japan; Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan; Department of Dermatology, Hyogo Medical University, Nishinomiya, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|February 26, 2023
PubMed
Summary

Group 2 innate lymphoid cells (ILC2s) play a role in skin homeostasis and atopic dermatitis (AD). Elevated IL-33 in AD keratinocytes activates ILC2s, contributing to disease pathogenesis.

Keywords:
AllergyAtopic dermatitisGroup 2 innate lymphoid cells (ILC2)IL-18IL-33

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Group 2 innate lymphoid cells (ILC2s) are crucial for tissue homeostasis, responding to tissue-derived factors.
  • Cutaneous ILC2s exhibit distinct properties and roles in skin health and disease.
  • Atopic dermatitis (AD) involves dysregulation of immune responses in the skin.

Purpose of the Study:

  • To review the tissue-specific properties of cutaneous ILC2s.
  • To discuss the involvement of ILC2s in human skin diseases, particularly atopic dermatitis.
  • To highlight challenges in ILC2 classification and research.

Main Methods:

  • Literature review of studies on ILC2s in skin and atopic dermatitis.
  • Analysis of cytokine signaling pathways (e.g., IL-33, IL-4) in ILC2 activation.
  • Examination of therapeutic interventions targeting ILC2s in AD.

Main Results:

  • Cutaneous ILC2s contribute to skin homeostasis in a steady state.
  • Overexpressed IL-33 in AD keratinocytes stimulates ILC2s, leading to type 2 cytokine production.
  • ILC2 numbers are upregulated in AD skin lesions and decrease with Dupilumab treatment.

Conclusions:

  • ILC2s are implicated in the pathogenesis of atopic dermatitis.
  • Challenges in defining and classifying cutaneous ILC2s hinder comparative research.
  • Further comprehensive studies are needed to fully understand cutaneous ILC2 function and heterogeneity.