Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

375
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
375
Blood Transfusion01:15

Blood Transfusion

645
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
645
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Tissue Transplantation01:24

Tissue Transplantation

448
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
448
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

11.0K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous Leukocytapheresis and Continuous Renal Replacement Therapy for Acute Myeloid Leukemia: A Case Report.

Journal of clinical apheresis·2026
Same author

Spatial distribution of rare earth elements in seawater and sediments, and bioaccumulation in plankton from the Yellow Sea.

Marine pollution bulletin·2026
Same author

Rare Anti-f(ce) Detected During Cross-Matching.

Clinical laboratory·2026
Same author

Factors associated with analytical errors in blood chemistry tests.

Clinical chemistry and laboratory medicine·2026
Same author

Bayesian machine learning framework for time-domain prediction of multirotor vehicle noisea).

The Journal of the Acoustical Society of America·2026
Same author

Analysis of Blood Group Antigens as Risk Factors for Thrombosis in Polycythemia Vera Patients.

Clinical laboratory·2026

Related Experiment Video

Updated: Aug 8, 2025

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.2K

Transfusion support in hematopoietic stem cell transplantation.

Dong Wook Jekarl1, Jae Kwon Kim1, Jay Ho Han1

  • 1Departments of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, Seoul, Korea.

Blood Research
|February 27, 2023
PubMed
Summary

Transfusion support is vital for hematopoietic stem cell transplantation (HSCT). Careful management of blood product compatibility, including leukocyte reduction and irradiation, is crucial to prevent adverse events and ensure patient safety.

Keywords:
ABO blood groupHematopoietic stem cell transplantationRhD blood groupTransfusion

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.3K
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

13.5K

Related Experiment Videos

Last Updated: Aug 8, 2025

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.2K
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.3K
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

13.5K

Area of Science:

  • Hematology
  • Transfusion Medicine
  • Immunology

Background:

  • Transfusion support is critical for hematopoietic stem cell transplantation (HSCT) recipients.
  • While leukocyte antigen (HLA) matching is prioritized, blood group incompatibilities (major, minor, bidirectional, RhD) can still occur.
  • These incompatibilities may complicate transfusions and lead to adverse events.

Purpose of the Study:

  • To highlight the importance of compatible blood transfusions in HSCT.
  • To discuss potential transfusion incompatibilities and adverse events in HSCT.
  • To outline strategies for mitigating transfusion-related risks in HSCT.

Main Methods:

  • Review of current practices in transfusion support for HSCT.
  • Discussion of leukocyte antigen (HLA) matching and blood group compatibility.
  • Consideration of leukocyte reduction and irradiation of blood products.

Main Results:

  • Major, minor, bidirectional, and RhD incompatibilities can arise despite HLA matching.
  • Leukocyte reduction is a common practice; irradiation is recommended for most products except plasma.
  • Effective patient management requires adherence to local guidelines and hospital transfusion committee protocols.

Conclusions:

  • Optimizing transfusion support in HSCT involves managing various incompatibilities.
  • Leukocyte reduction and appropriate irradiation are key interventions.
  • Implementing robust local transfusion guidelines and committees is essential for safe patient care.