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Published on: September 20, 2024
[FIRES Syndrome in a Preschool Child]
N V Skripchenko1,2, E Y Gorelik1, E S Egorova1
1Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg, Russia.
Insights
Febrile Infections-Related Epilepsy Syndrome (FIRES) is a severe epilepsy in children, often triggered by fever and potentially linked to human herpesvirus 6. Early intervention with polyfunctional drugs like Cytoflavin is recommended for intensive therapy.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Epileptology
Context:
- Severe epileptic syndromes pose significant challenges for pediatric neurologists and neuroresuscitators.
- Febrile Infections-Related Epilepsy Syndrome (FIRES) is a severe, drug-resistant epilepsy in children.
- FIRES development is often associated with hyperthermia and potentially human herpesvirus 6 infection.
Purpose:
- To present a clinical observation of FIRES syndrome in a pediatric patient.
- To highlight the progressive course and diagnostic challenges of FIRES.
- To describe empirical and pathogenetic treatment approaches for FIRES.
Summary:
- The case involves a pediatric patient with FIRES, characterized by severe epilepsy, fever, and respiratory symptoms.
- Diagnostic difficulties were encountered due to the progressive nature of the syndrome.
- An empirical approach to therapy was initiated, followed by a pathogenetic treatment strategy.
Impact:
- The study emphasizes the utility of polyfunctional drugs, specifically Cytoflavin, in managing FIRES.
- The authors recommend Cytoflavin as a primary option for intensive therapy in FIRES cases.
- This observation contributes to understanding and managing severe pediatric epilepsy syndromes.
Abstract:
Severe epileptic syndromes of childhood are an urgent problem for pediatric neurologists and neuroresuscitators. The article presents a clinical observation of FIRES syndrome in a pediatric patient, which is a form of severe drug-resistant epilepsy in children of preschool and school age, the development of which is caused by hyperthermia, probably associated with herpesvirus (human herpesvirus type 6) infection. The features of the progressive course and the difficulties of diagnostic search are reflected. An empirical approach to etiotropic therapy is described, since the disease manifested itself with respiratory manifestations and fever. The tactic of pathogenetic treatment is described, in which drugs of polyfunctional action, such as Cytoflavin, have a priority, many years of experience in the use of which allows the authors to recommend it as a starting intensive therapy.
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