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Experiences with iohexol (Omnipaque) at urography.

A Fjelldal1, T Nordshus, J Eriksson

  • 1Department of Radiology, Ullevål University Hospital, Oslo, Norway.

Pediatric Radiology
|January 1, 1987
PubMed
Summary

A new non-ionic contrast medium, iohexol, showed a very low reaction rate of 0.9% in pediatric intravenous pyelography. This safe and effective contrast agent is recommended for all pediatric age groups.

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Area of Science:

  • Radiology
  • Pediatric Imaging
  • Pharmacology

Background:

  • Intravenous pyelography (IVP) is a common diagnostic imaging procedure in pediatrics.
  • Contrast media reactions can cause patient discomfort and require management.
  • Non-ionic contrast media offer improved safety profiles compared to ionic agents.

Purpose of the Study:

  • To evaluate the safety and efficacy of a new non-ionic contrast medium, iohexol, in pediatric intravenous pyelography.
  • To determine the incidence of adverse reactions associated with iohexol in a pediatric population.

Main Methods:

  • Prospective study design.
  • Inclusion of 547 pediatric patients undergoing intravenous pyelography.
  • Administration of the non-ionic contrast medium iohexol.

Main Results:

  • A total of 5 minor adverse reactions were observed, resulting in a reaction rate of 0.9%.
  • No severe adverse events were reported.
  • The safety profile was consistent across neonates and older children.

Conclusions:

  • Iohexol is a safe and well-tolerated non-ionic contrast medium for pediatric intravenous pyelography.
  • The observed low incidence of adverse reactions supports its use in neonates and children.
  • The benefits of iohexol's safety profile justify its cost in pediatric imaging.

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