Follicular Variant of Acquired Dermal Macular Hyperpigmentation: A Case Report

Ammar A Bakhsh1, Basant A Alzubaidy1, Mohammed A Attas1

  • 1Faculty of Medicine, Umm Al Qura University, Makkah, SAU.

Cureus
|February 27, 2023
PubMed

Insights

This case report details a rare follicular form of acquired dermal macular hyperpigmentation (ADMH) in a 55-year-old woman. Treatment with topical steroids and tacrolimus showed some improvement in her skin condition.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Acquired dermal macular hyperpigmentation (ADMH) encompasses idiopathic macular dermal hypermelanosis conditions like erythema dyschromicum perstans and lichen planus pigmentosus.
  • These conditions present as hyperpigmentation of the skin.

Observation:

  • A 55-year-old woman presented with a four-year history of asymptomatic, slowly progressive, pinpoint follicular brown macules coalescing into patches on her neck, chest, upper extremities, and back.
  • Differential diagnoses included Darier disease and Dowling-Degos disease.

Findings:

  • Skin biopsies revealed follicular plugging, dermal pigment incontinence with melanophages, and mild perivascular/perifollicular mononuclear cell infiltrates.
  • The patient was diagnosed with a follicular variant of ADMH.

Implications:

  • This case highlights a rare follicular presentation of ADMH.
  • Treatment with topical corticosteroids and calcineurin inhibitors demonstrated partial efficacy, warranting further investigation into management strategies for this condition.

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