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Follicular Variant of Acquired Dermal Macular Hyperpigmentation: A Case Report
Ammar A Bakhsh1, Basant A Alzubaidy1, Mohammed A Attas1
1Faculty of Medicine, Umm Al Qura University, Makkah, SAU.
Abstract:
Acquired dermal macular hyperpigmentation (ADMH) is a term used to describe a group of diseases that are characterized by idiopathic macular dermal hypermelanosis. These skin conditions include erythema dyschromicum perstans, lichen planus pigmentosus, and pigmented contact dermatitis, also known as Riehl's melanosis. This case report involves a 55-year-old woman who was generally healthy but who had been experiencing asymptomatic, slowly progressive skin lesions for the previous four years. A thorough inspection of her skin revealed many non-scaly, pin-point follicular brown macules, which in some spots had coalesced into patches across her neck, chest, upper extremities, and back. Darier disease and Dowling-Degos disease were included in the differential diagnosis. The biopsies of the skin revealed follicular plugging. The dermis had pigment incontinence with melanophages and slight perivascular and perifollicular mononuclear cell infiltrates. The patient was diagnosed with a follicular form of ADMH. Patient's skin condition caused her concern. She was reassured and prescribed topical steroids 0.1% betamethasone valerate ointment application twice a day for two days per week (weekends) and 0.1% tacrolimus ointment application twice a day for five days per week for three months. She showed some improvement and was put under periodic follow-ups.
Insights
This case report details a rare follicular form of acquired dermal macular hyperpigmentation (ADMH) in a 55-year-old woman. Treatment with topical steroids and tacrolimus showed some improvement in her skin condition.
Area of Science:
- Dermatology
- Pathology
Background:
- Acquired dermal macular hyperpigmentation (ADMH) encompasses idiopathic macular dermal hypermelanosis conditions like erythema dyschromicum perstans and lichen planus pigmentosus.
- These conditions present as hyperpigmentation of the skin.
Observation:
- A 55-year-old woman presented with a four-year history of asymptomatic, slowly progressive, pinpoint follicular brown macules coalescing into patches on her neck, chest, upper extremities, and back.
- Differential diagnoses included Darier disease and Dowling-Degos disease.
Findings:
- Skin biopsies revealed follicular plugging, dermal pigment incontinence with melanophages, and mild perivascular/perifollicular mononuclear cell infiltrates.
- The patient was diagnosed with a follicular variant of ADMH.
Implications:
- This case highlights a rare follicular presentation of ADMH.
- Treatment with topical corticosteroids and calcineurin inhibitors demonstrated partial efficacy, warranting further investigation into management strategies for this condition.
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