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COVID-19 Infection and Acute Pancreas Transplant Graft Thrombosis
Umasankar Mathuram Thiyagarajan1, Khaled Dajani1, Blaire Anderson1
1Department of Hepatobiliary and Pancreatic Surgery and Transplantation, University of Alberta Hospital, Edmonton, CAN.
Insights
A rare case of late pancreas graft thrombosis occurred 13 years after pancreas-after-kidney transplantation. This event coincided with a COVID-19 infection in a vaccinated patient, highlighting a potential complication in transplant recipients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Infectious Diseases
Background:
- The COVID-19 pandemic poses significant risks to healthcare systems globally.
- COVID-19 is associated with hypercoagulable states, leading to ischemia and increased mortality.
- Solid organ transplant recipients are particularly vulnerable to severe COVID-19 complications.
Abstract:
The coronavirus disease 2019 (COVID-19) pandemic created an unprecedented challenge for healthcare, and the world continues to struggle in recovering from its aftermath. COVID-19 has been clearly linked to hypercoagulable states and can lead to end-organ ischemia, morbidity, and mortality. Immunosuppressed solid organ transplant recipients represent a highly vulnerable population for the increased risk of complications and mortality. Early venous or arterial thrombosis with acute graft loss after whole pancreas transplantation is well-described, but late thrombosis is rare. We herein report a case of acute, late pancreas graft thrombosis at 13 years post pancreas-after-kidney (PAK) transplantation coinciding with an acute COVID-19 infection in a previously double-vaccinated recipient.
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