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An overview on monkeypox virus: Pathogenesis, transmission, host interaction and therapeutics
Shailima Rampogu1, Yongseong Kim2, Seon-Won Kim3
1Department of Bio & Medical Big Data (BK4 Program), Division of Life Sciences, Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), Jinju, Republic of Korea.
Frontiers in Cellular and Infection Microbiology
|February 27, 2023
Summary
Monkeypox (MPV) is a growing global health emergency. This review covers MPV structure, transmission, and limited therapeutics, urging further scientific research.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Monkeypox (MPV), a zoonotic disease within the Orthopoxvirus genus, is rapidly spreading globally.
- Increasing incidence rates and human-to-human transmission highlight MPV as a significant public health concern.
- The World Health Organization (WHO) has declared MPV a global health emergency due to its rapid spread and limited treatment options.
Purpose of the Study:
- To review the structure, transmission modes, and therapeutic options for Monkeypox virus (MPV).
- To provide insights into host-virus interactions and identify key genes involved in MPV infection.
- To encourage further research within the scientific community to address the MPV outbreak.
Main Methods:
- Literature review focusing on Orthopoxvirus and Monkeypox virus.
- Analysis of host-virus interactions to identify significantly expressed genes.
- Synthesis of information on MPV structure, transmission, and current therapeutic strategies.
Main Results:
- MPV exhibits rapid human-to-human and animal-to-human transmission, contributing to its global spread.
- Host-virus interaction studies reveal specific genes crucial for MPV infection progression.
- Current therapeutic options for MPV are limited, underscoring the need for further development.
Conclusions:
- Understanding MPV transmission and symptoms is critical for disease control.
- Further research into MPV pathogenesis and host-virus interactions is essential.
- Development of novel therapeutic strategies is urgently needed to combat the escalating MPV crisis.
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