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Updated: Aug 8, 2025
06:03
Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules
Published on: May 23, 2015
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Primary pulmonary diffuse large B-cell lymphoma presenting multiple nodules mimicking metastasis: A case report
Nobuhiro Fujioka1, Yoshiro Kai2, Ryosuke Kataoka2
1Department of Respiratory Medicine Nara Medical University Nara Japan.
Respirology Case Reports
|February 27, 2023
Summary
Primary pulmonary diffuse large B-cell lymphoma is rare. This case highlights its potential to mimic metastases in rheumatoid arthritis patients, emphasizing the need for consideration in differential diagnoses.
Area of Science:
- Oncology
- Pulmonology
- Rheumatology
Background:
- Rheumatoid arthritis (RA) is an autoimmune disease often treated with immunosuppressants.
- Patients with RA may have an increased risk of certain malignancies.
- Pulmonary involvement in RA can manifest in various forms.
Observation:
- A 73-year-old male with a history of RA treated with leflunomide presented with new-onset multiple pulmonary nodules.
- Chest CT revealed multiple nodules, and PET/CT showed variable FDG uptake.
- Video-assisted thoracic surgical biopsy confirmed primary pulmonary diffuse large B-cell lymphoma.
Findings:
- Primary pulmonary diffuse large B-cell lymphoma (PDLBCL) can present as multiple nodules.
- PDLBCL in RA patients may mimic metastatic disease.
- Systemic chemotherapy (R-CVP) effectively treated the pulmonary lymphoma.
Implications:
- Pulmonary lymphoma should be included in the differential diagnosis for patients with RA presenting with multiple pulmonary nodules.
- Early diagnosis and treatment are crucial for managing PDLBCL.
- This case underscores the importance of vigilant monitoring in RA patients with pulmonary findings.
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