Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Scientific Method02:40

The Scientific Method

59.9K
Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
59.9K
Modeling in Therapy01:26

Modeling in Therapy

130
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
130
Elements Crucial for Effective Psychotherapy01:25

Elements Crucial for Effective Psychotherapy

94
Research has highlighted several critical factors that influence the effectiveness of psychotherapy, such as the therapeutic alliance, the therapist, and the client.
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...
94

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Systemic Vibratory Therapy Combined with a Physical Activity Program in Older Adults on Fall Risk, Balance, Physical Conditioning, and Neuromuscular Variables: Study Protocol for a Randomized Controlled Trial.

Healthcare (Basel, Switzerland)·2026
Same author

Crossfit® participants who experience reduced glenohumeral rotation movement and dynamic stability are more likely to report subacromial pain syndrome: A case‒control study.

Journal of bodywork and movement therapies·2026
Same author

Translation, cross-cultural adaptation, and measurement properties of the Back pain knowledge and beliefs survey (BacKS) for the Brazilian population.

Brazilian journal of physical therapy·2026
Same author

Shifting the focus of ischemic preconditioning in exercise performance: from acute to chronic effects.

European journal of applied physiology·2026
Same author

C5-C6 and thoracic spine mobilization with postural correction exercise compared with conventional therapy in patients with adhesive capsulitis: a two-group, parallel-arm, single-blinded, randomized clinical trial-study protocol.

Trials·2026
Same author

Keeping the abdomen relaxed versus contracted during Pilates improves disability slightly and may improve other outcomes in chronic non-specific low back pain: a randomised trial.

Journal of physiotherapy·2026

Related Experiment Video

Updated: Aug 8, 2025

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model
07:34

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

767

Mediation Analysis in Manual Therapy Research.

Thiago da Silva Rocha Paz1, Pedro Teixeira Vidinha Rodrigues2, Bruno Moreira Silva3

  • 1Physical Education Postgraduation Program, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Chiropractic Medicine
|February 27, 2023
PubMed
Summary

Spinal manipulation did not significantly alter heart rate variability (HRV) through pain intensity, duration, or blood pressure in patients with musculoskeletal pain. The direct effects of spinal manipulation on cardiac autonomic control are likely intervention-based.

Keywords:
Heart RateManipulation, SpinalMediation AnalysisMusculoskeletal Manipulations

More Related Videos

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective
06:14

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective

Published on: January 12, 2024

2.0K
Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:05

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

590

Related Experiment Videos

Last Updated: Aug 8, 2025

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model
07:34

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

767
Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective
06:14

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective

Published on: January 12, 2024

2.0K
Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:05

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

590

Area of Science:

  • Manual Therapy
  • Cardiovascular Autonomic Control
  • Musculoskeletal Pain

Background:

  • Manual therapy is increasingly studied for its effects on musculoskeletal pain.
  • Understanding the mechanisms underlying manual therapy's effectiveness, such as its impact on cardiovascular autonomic control, is crucial.
  • Mediation analysis offers a framework to explore these underlying mechanisms.

Purpose of the Study:

  • To investigate the applicability of mediation analysis in manual therapy research.
  • To determine if pain intensity, pain duration, or systolic blood pressure changes mediate the effect of manual therapy on heart rate variability (HRV) in patients with musculoskeletal pain.

Main Methods:

  • Secondary data analysis of a randomized, placebo-controlled trial involving spinal manipulation, myofascial manipulation, and placebo groups.
  • Assessment of cardiovascular autonomic control using resting HRV (LF/HF ratio) and blood pressure response to a cold pressor test.
  • Mediation models were employed to analyze the relationships between intervention, potential mediators (pain intensity, duration, blood pressure), and HRV outcomes.

Main Results:

  • Spinal manipulation showed a statistically significant total effect on HRV outcomes compared to placebo (β = 0.77).
  • No statistical evidence supported mediation by pain intensity or its relationship with HRV.
  • No statistical evidence supported mediation by systolic blood pressure responsiveness.

Conclusions:

  • Pain intensity, pain duration, and systolic blood pressure responsiveness did not mediate the effects of spinal manipulation on cardiovascular autonomic control in patients with musculoskeletal pain.
  • The immediate impact of spinal manipulation on cardiac vagal modulation in this population is likely a direct effect of the intervention itself, rather than mediated by the investigated factors.