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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Other Stress Responses in Bacteria01:30

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Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
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Homeostatic Imbalances in Body Temperature01:19

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Responses to Heat and Cold Stress02:45

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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
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Decreased Body Temperature01:29

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
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Updated: Aug 8, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
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ZBP1 and heatstroke.

Fanglin Li1,2, Jiayi Deng1, Qiuli He3

  • 1Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Immunology
|February 27, 2023
PubMed
Summary
This summary is machine-generated.

Heatstroke is a deadly heat stress condition. This study reveals Z-DNA-binding protein 1 (ZBP1) as a key regulator in heatstroke pathology, uncovering a new function beyond its nucleic acid sensing role.

Keywords:
RIPK3ZBP1heatstrokenecroptosisprogrammed cell death

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Area of Science:

  • Immunology
  • Pathophysiology
  • Molecular Biology

Background:

  • Heatstroke is a life-threatening condition caused by heat stress, leading to circulatory failure and organ dysfunction.
  • Its underlying mechanisms remain poorly understood, despite its increasing prevalence due to global warming.
  • Z-nucleic acid sensor Z-DNA-binding protein 1 (ZBP1) has known roles in cell death and inflammation, but its full function is unclear.

Purpose of the Study:

  • To investigate the role of Z-DNA-binding protein 1 (ZBP1) in the pathogenesis of heatstroke.
  • To elucidate the signaling pathways regulated by ZBP1 in heatstroke.
  • To identify novel mechanisms contributing to heatstroke lethality.

Main Methods:

  • Review of main regulators involved in heatstroke pathology.
  • Identification of ZBP1 as a significant factor in heatstroke.
  • Analysis of ZBP1-dependent signaling in heatstroke.

Main Results:

  • Z-DNA-binding protein 1 (ZBP1) was identified as a key regulator of heatstroke's pathological characteristics.
  • ZBP1-dependent signaling pathways significantly influence heatstroke progression.
  • A novel function of ZBP1 in heatstroke lethality was revealed.

Conclusions:

  • ZBP1 plays a critical role in the lethal mechanisms of heatstroke.
  • ZBP1's function extends beyond nucleic acid sensing to regulating heatstroke pathology.
  • Understanding ZBP1's role offers new insights into heatstroke treatment strategies.