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Platforms, advances, and technical challenges in virus-like particles-based vaccines
Reeshu Gupta1, Kajal Arora1, Sourav Singha Roy1
1Department of Research and Development, Premas Biotech Pvt Ltd., Sector IV, Industrial Model Township (IMT), Manesar, Gurgaon, India.
Frontiers in Immunology
|February 27, 2023
Summary
Virus-like particle (VLP) vaccines offer a promising approach to combat viral diseases due to their safety and immunogenicity. This review explores VLP platforms, production challenges, and the current status of VLP vaccine development.
Area of Science:
- Biotechnology
- Immunology
- Vaccinology
Background:
- Viral infectious diseases pose significant global health threats.
- Virus-like particles (VLPs) are non-infectious, highly immunogenic vaccine candidates with structural similarity to viruses.
- While successful, few VLP vaccines are commercialized, with many facing development hurdles.
Purpose of the Study:
- To review the advantages and disadvantages of various VLP production platforms.
- To discuss recent advancements and technical challenges in VLP manufacturing.
- To outline the current development status of VLP-based vaccine candidates.
Main Methods:
- Comprehensive literature review of VLP vaccine platforms.
- Analysis of technical challenges in large-scale VLP production.
- Assessment of VLP vaccine candidates across commercial, clinical, and preclinical stages.
Main Results:
- VLPs offer a safe and effective vaccine strategy against viral infections.
- Key challenges in VLP production include scalable manufacturing, process optimization, and quality control.
- Several VLP vaccine candidates are progressing through different development phases.
Conclusions:
- VLP technology holds significant potential for addressing existing and emerging viral diseases.
- Overcoming manufacturing and technical challenges is crucial for successful commercialization of VLP vaccines.
- Continued research and development are essential to advance VLP-based vaccine candidates.
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