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Updated: Aug 8, 2025

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hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts

Yifei Wang1,2, Yaqin Zhang1,2, Bing Lu3

  • 1Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Jiangsu University, 213017 Changzhou, China.

Stem Cells International
|February 27, 2023
PubMed
Summary

Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) alleviate intestinal fibrosis in IBD models. These exosomes inhibit fibroblast activity by reducing ERK phosphorylation, offering a potential new treatment for IBD-related fibrosis.

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