Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

174
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
174

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and evaluation of injectable niclosamide nanocrystals prepared by wet media milling technique.

Drug development and industrial pharmacy·2014
Same author

Downregulation of leaf flavin content induces early flowering and photoperiod gene expression in Arabidopsis.

BMC plant biology·2014
Same author

Fluoride affects calcium homeostasis and osteogenic transcription factor expressions through L-type calcium channels in osteoblast cell line.

Biological trace element research·2014
Same author

Malignant melanoma of the vagina: A case report and review of the literature.

Oncology letters·2014
Same author

Synthesis and reactivity of new aminophenolate complexes of nickel.

Molecules (Basel, Switzerland)·2014
Same author

Electrochemical immunosensor for α-fetoprotein detection using ferroferric oxide and horseradish peroxidase as signal amplification labels.

Analytical biochemistry·2014

Related Experiment Video

Updated: Aug 8, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.7K

Mannose-coated superparamagnetic iron oxide nanozyme for preventing postoperative cognitive dysfunction.

Qianyun Zhu1, Yuting Huang1, Xiaoling Zhu1

  • 1Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, PR China.

Materials Today. Bio
|February 27, 2023
PubMed
Summary

Mannose-coated nanoparticles effectively scavenge reactive oxygen species and reduce inflammation, preventing cognitive decline after surgery. This nanozyme approach offers a promising strategy for treating postoperative cognitive dysfunction.

Keywords:
NanoparticlesNeuroinflammationPostoperative cognitive dysfunctionReactive oxygen species

More Related Videos

Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model
10:03

Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model

Published on: November 21, 2019

7.7K
Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

8.8K

Related Experiment Videos

Last Updated: Aug 8, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.7K
Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model
10:03

Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model

Published on: November 21, 2019

7.7K
Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

8.8K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Neuroscience

Background:

  • Postoperative cognitive dysfunction (POCD) increases patient morbidity and mortality.
  • Reactive oxygen species (ROS) and inflammation in the brain are key contributors to POCD.
  • Challenges exist in delivering ROS scavengers across the blood-brain barrier (BBB) for POCD prevention.

Purpose of the Study:

  • To synthesize and evaluate mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) for POCD prevention.
  • To assess the BBB penetration and in vivo efficacy of mSPIONs.
  • To investigate the ROS scavenging and anti-inflammatory effects of mSPIONs on cognitive function.

Main Methods:

  • mSPIONs synthesized via co-precipitation, characterized for size (~11 nm).
  • BBB penetration confirmed using fluorescent imaging and ICP-MS.
  • ROS scavenging and anti-inflammatory activity assessed in vitro (H2O2-treated cells) and in vivo (surgical mice).
  • Cognitive function evaluated using Novel Object Recognition (NOR) and Trace Fear Conditioning (TFC) tests.

Main Results:

  • mSPIONs demonstrated significant ROS reduction in cells and mouse hippocampus.
  • mSPIONs decreased IL-1β and TNF-α levels and inhibited the HIF1-α/NF-κB pathway in the hippocampus.
  • Administration of mSPIONs significantly improved cognitive function in postoperative mice.

Conclusions:

  • Mannose-coated nanoparticles represent a novel nanozyme approach for POCD prevention.
  • mSPIONs effectively cross the BBB and exert ROS scavenging and anti-inflammatory effects.
  • This study presents a promising strategy for mitigating cognitive deficits following surgery.