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Ligand Binding Sites02:40

Ligand Binding Sites

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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Biomedical applications of solid-binding peptides and proteins.

Nicolò Alvisi1, Renko de Vries1

  • 1Physical Chemistry and Soft Matter, Wageningen University & Research, Stippeneng 4, 6708WE, Wageningen, the Netherlands.

Materials Today. Bio
|February 27, 2023
PubMed
Summary

Solid-binding peptides (SBPs) are versatile tools for immobilizing biomolecules onto various surfaces. This review highlights their crucial role in advancing biomedical applications like drug delivery and biosensing.

Keywords:
Adsorption-based coatingsBioconjugationBiomaterialsBiomedicineBiosensingImplantsProtein designSolid-binding peptidesSolid-binding proteinsSurface coatings

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biotechnology

Background:

  • Solid-binding peptides (SBPs) are effective for non-covalent surface modification, enabling biomolecule immobilization on diverse materials.
  • SBPs enhance biocompatibility in physiological settings and allow tunable display of biomolecules with preserved functionality.
  • These peptides are integral to developing bioinspired materials for diagnostics and therapeutics.

Purpose of the Study:

  • To review the recent literature on solid-binding peptides and proteins in biomedical applications.
  • To focus on applications where controlling solid material-biomolecule interactions is critical.
  • To provide background on SBP design, binding mechanisms, and applications on various biomedical materials.

Main Methods:

  • Literature review of solid-binding peptides and proteins in biomedical applications.
  • Analysis of SBP applications on materials including calcium phosphates, silicates, metals, plastics, and graphene.
  • Discussion of SBP sequence design and binding mechanisms.

Main Results:

  • SBPs are successfully applied to a wide range of biomedical materials, including nanomaterials.
  • SBP-mediated bioconjugation is adaptable to complex designs and diverse surface chemistries.
  • Despite characterization challenges, SBPs offer significant potential for biomedical innovations.

Conclusions:

  • Solid-binding peptides are valuable tools for creating advanced biomaterials for diagnostics and therapeutics.
  • Their versatility in surface modification and biomolecule display drives innovation in drug delivery, biosensing, and regenerative medicine.
  • Further characterization of SBPs will enhance their design and broaden their widespread application in biomedicine.