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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Chronic Inflammatory Demyelinating Polyneuropathy After Therapy With Infliximab Biosimilar
Jessica Larson1, Patrick Twohig2, Kathryn Hutchins2
1Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
Abstract:
Tumor necrosis factor-α inhibitors are monoclonal antibodies that are commonly used in the treatment of inflammatory bowel disease. A rare side effect of these biological agents is chronic inflammatory demyelinating polyneuropathy, which is a debilitating disease characterized by weakness, sensory dysfunction, and diminished or absent reflexes. We present the first reported case of chronic inflammatory demyelinating polyneuropathy after treatment with the tumor necrosis factor-α inhibitor biosimilar, infliximab-dyyp (Inflectra).
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