Associations between cardiac structure and function and depressive disorder: A centenarian study in China
Zhigao Sun1, Ping Ping2, Pei Zhang3
1Traditional Chinese Medicine Department, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
Insights
Depressive disorder is prevalent in centenarians, with higher left ventricular ejection fraction and interventricular septum thickness linked to its presence. Further research is needed to understand these cardiac associations for healthy aging.
Area of Science:
- Gerontology
- Cardiology
- Psychiatry
Background:
- Depressive disorder frequently co-occurs with cardiovascular diseases, increasing mortality risks.
- The link between cardiac structure/function and depression in centenarians is not well understood.
- Centenarians represent a unique population for studying aging-related health conditions.
Purpose of the Study:
- To investigate the association between cardiac structure and function and depressive disorder in centenarians.
- To identify specific cardiac parameters related to depressive disorder in this extreme age group.
Main Methods:
- Utilized data from the China Hainan Centenarian Cohort Study.
- Assessed depressive disorder using the 15-item Geriatric Depression Scale.
- Evaluated cardiac structure and function via echocardiography.
Main Results:
- A high prevalence of depressive disorder (26.2%) was observed in 682 centenarians.
- Depressive disorder was associated with significantly higher left ventricular ejection fraction and interventricular septum thickness.
- Left ventricular ejection fraction and interventricular septum thickness were independently associated with depressive disorder.
Conclusions:
- Depressive disorder is common in Chinese centenarians, with significant cardiac associations.
- Left ventricular ejection fraction and interventricular septum thickness may play a role in depressive disorder among the oldest old.
- Future research should explore temporal relationships to improve cardiac health and prevent depression in aging populations.
Background:
Depressive disorder is a common comorbidity in patients with cardiovascular diseases and is associated with increased hospitalization and death rates. The relationships between cardiac structure and function and depressive disorder remains unclear in the older adults, especially in centenarians. Therefore, this study aimed to explore the possible associations between cardiac structure and function and depressive disorder among centenarians.
Methods:
In the China Hainan Centenarian Cohort Study, the 15-item Geriatric Depression Scale scores and echocardiography were used to evaluate depressive disorder and cardiac structure and function, respectively. All information, including epidemiological questionnaires, physical examinations, and blood tests, was obtained following standardized procedures.
Results:
A total of 682 centenarians were enrolled in the study (mean age: 102.35 ± 2.72 years). The prevalence of depressive disorder in centenarians is 26.2% (179 older adults), of whom 81.2% (554 older adults) are women. Centenarians with depressive disorder have significantly higher left ventricular ejection fraction (60.02 ± 3.10) and interventricular septum thickness (9.79 ± 1.54). Stepwise multiple linear regression analysis detected positive associations of left ventricular ejection fraction (Bets: 0.093) and interventricular septum thickness (Bets: 0.440) with Geriatric Depression Scale scores. Both left ventricular ejection fraction (odds ratio: 1.081) and interventricular septum thickness (odds ratio: 1.274) were independently associated with depressive disorder in multiple logistic regression analysis (P < 0.05, all).
Conclusions:
The prevalence of depressive disorder remains very high, and associations were found between left ventricular ejection fraction, interventricular septum thickness, and depressive disorder in Chinese centenarians. Future studies should focus on their temporal relationships to improve cardiac structure and function, prevent depressive disorder, and achieve healthy aging by coordinating their relationships.
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