Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

369
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
369
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

851
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
851
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

134
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
134
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.5K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.5K
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

588
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
588
Osmosis and Osmotic Pressure of Solutions02:40

Osmosis and Osmotic Pressure of Solutions

40.6K
A number of natural and synthetic materials exhibit selective permeation, meaning that only molecules or ions of a certain size, shape, polarity, charge, and so forth, are capable of passing through (permeating) the material. Biological cell membranes provide elegant examples of selective permeation in nature, while dialysis tubing used to remove metabolic wastes from blood is a more simplistic technological example. Regardless of how they may be fabricated, these materials are generally...
40.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wave propagation in fluid-saturated nanoporous media: Upscaling molecular mechanics into continuum-level description.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Adsorption-Induced Pore Volume Deformation: Implications for Excess Adsorption in Kerogen Matrices.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Adsorption of Forever Chemical Pollutants: The Physical Chemistry of PFAS Near Surfaces.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Interplay of structure and dynamics in solid polymer electrolytes: a molecular dynamics study of LiPF<sub>6</sub>/polypropylene carbonate.

Physical chemistry chemical physics : PCCP·2026
Same author

On-demand formation of ultrathin liquid metal hydrogel tattoos for conformal and low-impedance bioelectronics.

Science advances·2026
Same author

Physical Properties of Nanoconfined Methane Hydrate: Structure, Thermoelasticity, and Thermal Conductivity.

Langmuir : the ACS journal of surfaces and colloids·2026

Related Experiment Video

Updated: Aug 8, 2025

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

25.4K

Sorption-Deformation-Percolation Model for Diffusion in Nanoporous Media.

Chi Zhang1, Ali Shomali1, Benoit Coasne2

  • 1Chair of Building Physics, Department of Mechanical and Process Engineering, ETH Zurich, Rämistrasse 101, 8092 Zürich, Switzerland.

ACS Nano
|February 27, 2023
PubMed
Summary

A new model explains molecular diffusion in porous materials, linking tortuosity to adsorption heat, elastic modulus, and percolation probability. This offers insights into material behavior and diffusion control.

Keywords:
diffusionmodulusmolecular dynamicspercolationsorption

More Related Videos

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

6.5K
Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.4K

Related Experiment Videos

Last Updated: Aug 8, 2025

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

25.4K
In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

6.5K
Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
06:01

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

1.4K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Physical Chemistry

Background:

  • Molecular diffusion in porous media is crucial for many applications.
  • Existing models struggle with complex pore structures and molecule-host interactions, especially at small scales.

Purpose of the Study:

  • To develop a semi-empirical model for diffusion in porous media.
  • To link diffusion dynamics to material structure and behavior (sorption, deformation).

Main Methods:

  • Utilized molecular dynamics simulations.
  • Formulated a semi-empirical model based on theoretical considerations and factorization.
  • Analyzed intermittent dynamics of water diffusion.

Main Results:

  • Predicted microscopic self-diffusion coefficients.
  • Apparent tortuosity quantitatively depends on heat of adsorption, elastic modulus, and percolation probability.
  • These parameters are experimentally accessible.

Conclusions:

  • The proposed sorption-deformation-percolation model enhances understanding of diffusion in complex media.
  • Provides a framework for fine-tuning diffusion processes through material property control.