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Related Experiment Video

Updated: Aug 8, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

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Intratympanic gentamicin for Ménière's disease.

Katie E Webster1, Kevin Galbraith1, Ambrose Lee2

  • 1Cochrane ENT, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

The Cochrane Database of Systematic Reviews
|February 27, 2023
PubMed
Summary
This summary is machine-generated.

The efficacy of intratympanic gentamicin for Ménière

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Area of Science:

  • Otolaryngology
  • Neurology
  • Pharmacology

Background:

  • Ménière's disease is characterized by recurrent vertigo, hearing loss, and tinnitus.
  • Intratympanic aminoglycosides are used to treat Ménière's disease by targeting the vestibular system.
  • The effectiveness and safety of this treatment remain uncertain.

Purpose of the Study:

  • To evaluate the benefits and harms of intratympanic aminoglycosides compared to placebo or no treatment for Ménière's disease.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) and quasi-RCTs.
  • Searched multiple databases for relevant studies up to September 2022.
  • Primary outcomes included vertigo improvement, change in vertigo, and serious adverse events.

Main Results:

  • Five RCTs with 137 participants were included; all used gentamicin.
  • Evidence quality was very low due to small sample sizes and study limitations.
  • Some studies suggested potential improvement in vertigo, but results were inconclusive.

Conclusions:

  • The evidence for intratympanic gentamicin in Ménière's disease is highly uncertain.
  • Small sample sizes and varied methodologies prevent definitive conclusions.
  • Further research with standardized outcomes and safety assessments is needed.