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Primary malignant neoplasms associated with chronic lymphocytic leukaemia
M Lishner1, M Prokocimer, E Ron
1Division of Hematology, Beilinson Medical Center, Petah Tiqva, Israel.
Postgraduate Medical Journal
|April 1, 1987
Summary
Patients with chronic lymphocytic leukemia (CLL) have an increased risk of developing secondary cancers, particularly brain cancer. This study supports the hypothesis that CLL patients are prone to developing additional primary malignant neoplasms.
Area of Science:
- Oncology
- Hematology
Background:
- Chronic lymphocytic leukemia (CLL) is a hematologic malignancy.
- The risk of developing secondary cancers in CLL patients requires further investigation.
Purpose of the Study:
- To evaluate the relationship between chronic lymphocytic leukemia (CLL) and the risk of developing primary malignant neoplasms.
- To determine if CLL patients have a higher incidence of second cancers.
Main Methods:
- Retrospective analysis of 81 patients diagnosed with CLL between 1962 and 1984.
- Data sourced from Beilinson Medical Center's Hematology Division and the Israel Cancer Registry.
- Inclusion of all diagnosed primary malignant neoplasms, with exclusion of nonmelanoma skin tumors for risk assessment.
Main Results:
- 16 out of 81 CLL patients (20%) developed 21 additional malignant neoplasms.
- A statistically non-significant 1.7-fold increased risk for second neoplasms was observed in CLL patients (excluding nonmelanoma skin tumors).
- Brain cancer was the only tumor type found to occur significantly more often than expected after CLL diagnosis.
Conclusions:
- The findings support the hypothesis that patients with chronic lymphocytic leukemia (CLL) are prone to developing secondary neoplasms.
- CLL patients may have an elevated risk for specific secondary cancers, such as brain cancer.