Particulate matter in poultry house on poultry respiratory disease: a systematic review

Particulate matter (PM) is one of the essential environmental stressors for the poultry industry in the world. Given its large specific surface area, PM can adsorb and carry a variety of pollutants, including heavy metal ions, ammonia, and persistent organic pollutants such as pathogenic microorganisms. High concentrations of PM induce poultry respiratory inflammation and trigger various diseases. However, the pathogenic mechanism of PM in poultry houses on respiratory diseases has not been clarified due to its complexity and lack of accurate assays. In terms of pathogenesis, there are 3 ways to explain this phenomenon: Inhaled PM irritates the respiratory tract, decreases immune resistance, and causes a respiratory disease; respiratory tract irritation by compounds presents in PM; infections with pathogenic and non-pathogenic microorganisms attached to PM. The latter 2 modes of influence are more harmful. Specifically, PM can induce the respiratory disease through several toxic mechanisms, including ammonia ingestion and bioaccumulation, lung flora dysbiosis, oxidative stress, and metabolic disorders. Therefore, this review summarizes the characteristics of PM in the poultry house and the impact of poultry PM on respiratory disease and proposes potential pathogenic mechanisms.