Alkaline phosphatase activities following repeated suramin administration in some rat tissues in relation to their...

The effect of repeated administration of suramin, a trypanocide and filariacide, on the level of alkaline phosphatase activity in some rat tissues and organs was investigated. Daily administration of this drug to rats resulted in a very significant increase in enzyme activity in the kidney and small intestine immediately after the first dose. Activity observed in the liver was not affected until after the third dose when the level was increased. In the heart and the large intestine, administration of the drug did not affect the enzyme activity levels throughout the duration of drug administration. These results suggest that repeated suramin administration may result in very large increases in alkaline phosphatase activity in the tissues and organs which are involved in active transport mechanisms.