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In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears
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Endolymphatic hydrops imaging and correlation with clinical characteristics, audiovestibular function and mental

Ying Hu1, Yue Zhang2, Xu Zhao1

  • 1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, People's Republic of China.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|February 27, 2023
PubMed
Abstract

Insights

MR imaging reveals endolymphatic hydrops in Meniere's disease, correlating with hearing loss and vertigo. This imaging helps assess disease severity and its impact on patients' emotional well-being.

Area of Science:

  • Otorhinolaryngology
  • Neurology
  • Radiology

Background:

  • Meniere's disease (MD) is characterized by endolymphatic hydrops (EH).
  • Accurate visualization and quantification of EH are crucial for diagnosis and management.
  • Understanding the relationship between EH and clinical manifestations is essential.

Purpose of the Study:

  • To visualize vestibular and cochlear endolymphatic hydrops in Meniere's disease patients using MR imaging.
  • To investigate the correlation between the degree of hydrops and clinical characteristics, audiovestibular function, and psychological state.

Main Methods:

  • 70 patients with unilateral Meniere's disease underwent bilateral intratympanic gadolinium administration and MR scanning.
  • 3D-real inversion recovery sequence was used to evaluate the degree of vestibular and cochlear hydrops.
  • Correlations were analyzed between hydrops grades and clinical data, hearing loss, vestibular tests (caloric, VEMP, EcoG), and psychological scales (DHI, SAS, SDS).

Main Results:

  • Endolymphatic hydrops were observed in both affected and contralateral ears, with no significant difference between left and right vestibules.
  • Vestibular EH (V-EH) positively correlated with cochlear EH (C-EH), hearing loss, VEMP, caloric tests, disease duration, and vertigo duration.
  • C-EH correlated positively with hearing loss and EcoG.
  • Psychological distress (DHI(E), SAS, SDS) was associated with VEMP, DHI(E), and DHI total scores.

Conclusions:

  • Endolymph-enhancing MRI is a valuable tool for diagnosing labyrinthine hydrops in Meniere's disease.
  • EH degree correlates with vertigo severity, hearing loss, vestibular function, and emotional changes, including anxiety and depression.
Keywords:
AnxietyDepressionEndolymphatic hydropsMeniere’s diseaseVestibular function

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