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Fibrinopeptide A increases after chorionic villus sampling.

F Al-Gailani1, S Elias, J L Simpson

  • 1Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.

Prenatal Diagnosis
|October 1, 1987
PubMed
Summary
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Trans-cervical chorionic villus sampling (CVS) may cause fibrin formation. Fibrinopeptide A levels increased in some women, indicating clotting without significant fibrinolysis, suggesting a potential risk during the procedure.

Area of Science:

  • Reproductive Medicine
  • Hematology
  • Obstetrics

Background:

  • Trans-cervical chorionic villus sampling (CVS) is a common prenatal diagnostic procedure.
  • Understanding the hemostatic changes associated with CVS is crucial for patient safety.

Purpose of the Study:

  • To investigate the impact of CVS on coagulation and fibrinolysis markers.
  • To assess whether CVS induces fibrin formation and if it is compensated by fibrinolysis.

Main Methods:

  • Fibrinopeptide A and B beta peptide levels were measured in 20 women undergoing CVS.
  • Analysis focused on changes in these markers indicative of thrombin activity and fibrinolysis.

Main Results:

  • A significant increase in Fibrinopeptide A was observed in five out of 20 subjects.

Related Experiment Videos

  • No significant changes were detected in B beta peptide levels, suggesting limited fibrinolysis.
  • These findings indicate localized fibrin formation in a subset of patients.

    • Conclusions:

    • CVS may induce a modest, uncompensated fibrin formation in some women.
    • The observed hemostatic changes warrant further investigation into potential clinical implications.