Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Placenta creta and placenta praevia creta.

T Y Khong1, W B Robertson

  • 1Department of Histopathology, John Radcliffe Hospital, Headington, Oxford, UK.

Placenta
|July 1, 1987
PubMed
Summary

Placenta creta involves abnormal placental villi adherence to the myometrium due to defective early trophoblast-maternal tissue interaction. This leads to abnormal uterine circulation and placental invasion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amsterdam Placental Workshop Group Consensus Statement definitions revisited: Basal chronic villitis.

Virchows Archiv : an international journal of pathology·2025
Same author

Distribution of cord inflammation in cases with clinical suspicion of chorioamnionitis.

The Malaysian journal of pathology·2024
Same author

MicroRNA profiling in complete and partial hydatidiform moles.

The Malaysian journal of pathology·2023
Same author

Diagnostic utility of p57 immunohistochemistry and DNA ploidy analysis by fluorescence in situ hybridisation in hydatidiform moles.

The Malaysian journal of pathology·2021
Same author

Estimating umbilical cord flow resistance from measurements of the whole cord.

Placenta·2020
Same author

Placenta Accreta in an Oragnutan (Pongo abelii) and a Chimpanzee (Pan troglodytes).

Journal of comparative pathology·2020

Area of Science:

  • Reproductive Biology
  • Gynecologic Pathology
  • Maternal-Fetal Medicine

Background:

  • Placenta creta spectrum disorders involve abnormal placental adherence to the uterine wall.
  • Understanding the pathophysiology of placenta creta is crucial for managing severe obstetric complications.

Purpose of the Study:

  • To investigate the histological features of the placental bed in placenta creta and placenta praevia creta.
  • To elucidate the interaction between trophoblast and maternal uterine tissues in these conditions.

Main Methods:

  • Histological examination of hysterectomy specimens from patients with placenta creta and placenta praevia creta.
  • Analysis of villous adherence, decidual integrity, extravillous trophoblast morphology, and uteroplacental vasculature.

Main Results:

  • Placental villi directly contacted the myometrium in all cases, confirming placenta creta.
  • Extravillous trophoblast was predominantly uninuclear/binuclear, differing from normal late placentation.
  • Abnormal uteroplacental vasculature and defective trophoblast-decidual interaction were observed.

Conclusions:

  • Placenta creta results from defective early placentation, specifically impaired trophoblast-decidual interaction.
  • This defect causes abnormal placental adherence and invasion, alongside aberrant uteroplacental circulation.

Related Experiment Videos