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Related Experiment Video

Updated: Aug 8, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Increase in cerebral microbleeds and cognitive decline.

Shingo Mitaki¹, Masahiro Takamura², Shuhei Yamaguchi³

¹Department of Neurology, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, 693-8501, Japan. shingomi@med.shimane-u.ac.jp.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|February 28, 2023

Summary

Newly detected strictly lobar cerebral microbleeds (CMBs) are linked to cognitive decline. This prospective study in a Japanese cohort found these microbleeds impact executive function over time.

Keywords:

Cerebral microbleeds Executive function Japanese Wisconsin card sorting test

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Area of Science:

Neurology
Neuroimaging
Cognitive Science

Background:

Cerebral microbleeds (CMBs) are increasingly recognized for their clinical importance.
The link between CMBs and cognitive impairment remains controversial.
Limited data exist on the prospective association of new CMBs with cognitive decline.

Purpose of the Study:

To investigate the impact of newly detected CMBs on cognitive decline.
To analyze the association between new CMBs and changes in cognitive function in a Japanese health examination cohort.

Main Methods:

Prospective cohort study of 769 Japanese participants (mean age 61.6 years) with a 7.3-year follow-up.
CMBs classified by location; cognitive functions assessed using standardized tests.
Multiple linear regression analyses used to determine relationships between new CMBs and cognitive decline.

Main Results:

56 participants (7.3%) developed new CMBs; 16 had strictly lobar CMBs.
Newly detected strictly lobar CMBs correlated with significant decline in executive function.
Specifically, associations found with Wisconsin Card Sorting Test performance and increased perseverative errors.

Conclusions:

Strictly lobar cerebral microbleeds detected over time are associated with a decline in executive function.
This finding contributes to understanding the role of CMBs in cognitive impairment progression.