Related Experiment Video

Updated: Aug 8, 2025

Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

408

Association of HTR3B gene polymorphisms with depression and its executive dysfunction: a case-control study

Lina Wang1,2, Miao Wang3, Chaoben Zhao3

  • 1Department of Psychology, Shandong Normal University, Jinan, 250358, Shandong, China.

BMC Psychiatry
|February 28, 2023
PubMed

Insights

Genetic variations in the HTR3B gene are linked to depression and executive dysfunction. The A allele of rs1176744 may increase depression risk, while C alleles offer protection.

Area of Science:

  • Genetics
  • Neuroscience
  • Psychiatry

Background:

  • Previous research indicates a link between the HTR3B gene and depression.
  • This study explores the association between HTR3B gene polymorphisms and depression with executive dysfunction.

Purpose of the Study:

  • To investigate the relationship between HTR3B gene polymorphisms and depression.
  • To examine the impact of these polymorphisms on executive function in a Chinese Han population.

Main Methods:

  • Genotyping of six Single Nucleotide Polymorphism (SNP) sites in the HTR3B gene (rs10789970, rs4938056, rs12421126, rs1176744, rs2276305, rs12795805) in 229 patients with depressive disorder and 202 healthy controls.
  • Assessment of depression severity using the 24-item Hamilton Depression Scale (HAMD).
  • Evaluation of executive function through cognitive tests including Maze Test, Symbolic Coding Test, Spatial Span Inverse Order Test, Linking Test, and Emotional Management Test.

Main Results:

  • Significant differences in genotypic and allelic distributions of rs1176744 were observed between patients and controls (P < 0.01).
  • The A allele of rs1176744 was positively correlated with depression, with higher A allele carrier frequency in patients.
  • Carriers of the A allele at rs1176744 showed lower Spatial Span Inverse Order Test scores, while carriers of C alleles at rs1176744 and rs12795805 had higher scores.

Conclusions:

  • HTR3B gene polymorphisms may be associated with depression in the Chinese Han population.
  • The A allele of rs1176744 is potentially linked to increased risk for depression and executive dysfunction.
  • C alleles at rs1176744 and rs12795805 may act as protective factors against executive dysfunction in depressed patients.
Abstract

Keywords:
DepressionExecutive dysfunctionHTR3BPolymorphism

More Related Videos

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.6K
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.1K

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
648
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
149
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
312
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
137
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
120.7K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
290