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Overcoming Suppressive Tumor Microenvironment by Vaccines in Solid Tumor
Ya-Jia Xie1, Wen-Qian Liu1, Dan Li2
1State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Vaccines
|February 28, 2023
Summary
Therapeutic cancer vaccines, including cell, DNA, RNA, peptide, and virus-based types, train the immune system to fight cancer. This review summarizes strategies for developing these vaccines to overcome the tumor microenvironment.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Conventional vaccines enhance natural immunity against pathogens.
- Therapeutic cancer vaccines are a significant focus in anti-cancer therapy.
- Cancer vaccines aim to eradicate cancer cells by training the host immune system.
Purpose of the Study:
- To review potential strategies and technologies for developing therapeutic cancer vaccines.
- To highlight advancements in overcoming the suppressive tumor microenvironment in solid tumors using vaccines.
Main Methods:
- Categorization of cancer vaccines based on their main components: cell, DNA, RNA, peptide, and virus-based.
- Summary of the two primary rationales behind cancer vaccine action.
- Review of current strategies and technologies for cancer vaccine development.
Main Results:
- Cancer vaccines can be classified into five main types based on their composition.
- Vaccines function by training the immune system to recognize and eliminate cancer cells.
- Potential strategies exist for overcoming the tumor microenvironment in solid tumors.
Conclusions:
- Therapeutic cancer vaccines represent a promising approach to cancer treatment.
- Further development in vaccine strategies is crucial for overcoming challenges like the tumor microenvironment.
- This review provides a comprehensive overview of cancer vaccine development for solid tumors.
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