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Transmissible Gastroenteritis Virus: An Update Review and Perspective.
Yiwu Chen1, Yuanzhu Zhang1, Xi Wang1
1Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
Viruses
|February 28, 2023
Summary
Transmissible gastroenteritis virus (TGEV) poses a significant threat to pig farming, causing high mortality. This review covers TGEV biology, virulence, and potential zoonotic risks, aiding in its detection and prevention.
Area of Science:
- Veterinary Virology
- Molecular Biology
- Animal Husbandry
Background:
- Transmissible gastroenteritis virus (TGEV), an alphacoronavirus, causes severe losses in pig farming with high piglet mortality.
- Recent TGEV evolution and recombination complicate detection and prevention efforts.
- Cross-species transmission of recombinant strains raises concerns.
Purpose of the Study:
- To review the biological properties of TGEV.
- To discuss factors influencing TGEV virulence and viral receptors.
- To summarize recent advances in understanding TGEV-induced apoptosis and autophagy.
- To assess the potential zoonotic risk of TGEV.
Main Methods:
- Literature review and synthesis of existing research on TGEV.
- Analysis of TGEV biological characteristics, virulence factors, and host interactions.
- Examination of studies on viral infection-induced cellular processes (apoptosis, autophagy).
- Evaluation of evidence for TGEV zoonotic potential.
Main Results:
- TGEV exhibits complex biological properties and evolving genetic diversity.
- Virulence is influenced by various host and viral factors.
- TGEV infection triggers significant apoptosis and autophagy pathways in host cells.
- Detection of CCoV-HuPn-2018 in humans suggests a potential zoonotic risk.
Conclusions:
- A comprehensive understanding of TGEV biology and evolution is crucial for disease control.
- Further research into TGEV-induced cellular mechanisms can inform therapeutic strategies.
- The potential zoonotic nature of TGEV warrants increased surveillance and investigation.
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