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Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
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Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment

Aydin Huseynov1, Ibrahim Akin1, Daniel Duerschmied1

  • 1Department of Medicine, Cardiology, Angiology, Hemostasis, and Intensive Care Medicine, University Medical Center Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, DE 68167 Mannheim, Germany.

Viruses
|February 28, 2023
PubMed

Insights

Post-COVID patients frequently experience persistent cardiac arrhythmias, a significant challenge for healthcare providers. This review examines the prevalence, causes, and management of these heart rhythm disorders following SARS-CoV-2 infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Late sequelae of acute COVID-19 infection present ongoing challenges for healthcare professionals.
  • COVID-19 affects multiple organs, including the cardiovascular system, leading to persistent cardiopulmonary symptoms.
  • A significant percentage of patients (10-50%) experience symptoms like dyspnea, palpitations, and arrhythmias weeks to months after SARS-CoV-2 infection.

Purpose of the Study:

  • To review the prevalence of cardiac arrhythmias in post-COVID patients.
  • To explore the underlying pathologies contributing to COVID-19-associated arrhythmias.
  • To discuss the clinical management of distinct rhythm disorders in post-COVID individuals.

Main Methods:

  • Literature review on COVID-19-associated cardiac arrhythmias.
  • Analysis of pathomechanisms including direct myocardial injury and hyperinflammation.
  • Discussion of clinical management strategies for post-COVID arrhythmias.

Main Results:

  • The spectrum of COVID-19-associated arrhythmias is wide, stemming from diverse pathomechanisms.
  • Direct myocardial injury and abnormal consequences impacting cardiac electric instability are key factors.
  • The hyperinflammatory response of the host immune system plays a crucial role.

Conclusions:

  • Cardiac arrhythmias are a common and significant late sequela of COVID-19.
  • Understanding the multifactorial pathomechanisms is essential for effective management.
  • Clinical strategies for managing arrhythmias in post-COVID patients require further consideration.

Keywords:
cardiac arrhythmias and channelopathiescytokinesmyocardial injurypost-COVID syndromesystemic inflammation

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