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The Host Non-Coding RNA Response to Alphavirus Infection.
Mahgol Behnia1, Steven B Bradfute1
1Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Viruses
|February 28, 2023
Summary
Alphaviruses cause widespread human and animal diseases. This review examines host non-coding RNA responses to alphavirus infections, identifying knowledge gaps for future research.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Alphaviruses are globally significant pathogens causing diseases like arthritis and encephalitis.
- Non-coding RNAs (ncRNAs) are crucial regulators of cellular pathways.
- Research on ncRNA responses to alphavirus infection is emerging but less explored than mRNA responses.
Purpose of the Study:
- To review current knowledge on host cell ncRNA responses during alphavirus infections.
- To identify and highlight existing gaps in understanding ncRNA roles in alphavirus pathogenesis.
- To guide future research directions in alphavirus-ncRNA interactions.
Main Methods:
- Comprehensive literature review of studies on alphavirus infections and host ncRNA.
- Analysis of reported ncRNA expression profiles and functional data.
- Synthesis of findings to identify trends and knowledge deficits.
Main Results:
- Alphavirus infection elicits diverse host ncRNA responses, including microRNAs and long non-coding RNAs.
- Specific ncRNAs have been implicated in modulating viral replication and host immune evasion.
- Significant gaps remain in understanding the precise functions and regulatory networks of ncRNAs in alphavirus pathogenesis.
Conclusions:
- Host ncRNA responses are integral to alphavirus infection dynamics.
- Further investigation into ncRNA mechanisms is essential for developing novel therapeutic strategies.
- Targeting ncRNAs may offer new avenues for controlling alphavirus diseases.
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