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GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis

Liangliang Wang1, Lele Sun1, Hao Sun1

  • 1Department of Forensic Medicine, Shanxi Medical University, Jinzhong, China.

Heliyon
|February 28, 2023
PubMed

Insights

GPR65 (G protein-coupled receptor 65) shows varied expression across cancers, influencing tumor microenvironment and immune cells. This suggests GPR65 is a potential target for novel cancer immunotherapies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Inhibiting GPR65 (G protein-coupled receptor 65) shows promise for cancer treatment.
  • The specific role of GPR65 in diverse cancer types is not fully understood.

Purpose of the Study:

  • To perform a comprehensive pan-cancer analysis of GPR65 expression and its functional relevance.
  • To investigate the association of GPR65 with tumor characteristics and the tumor microenvironment (TME).

Main Methods:

  • Utilized multiple public databases: TCGA, GTEx, BioGPS, HPA, cBioPortal, and GeneCards.
  • Conducted an exhaustive pan-cancer analysis of GPR65 expression patterns and correlations.

Main Results:

  • GPR65 exhibits differential expression in various cancers, impacting tumor mutational burden (TMB), microsatellite instability (MSI), and ploidy.
  • GPR65 influences T-helper cell subsets (Th1, Th2, Th17) within the tumor microenvironment.
  • GPR65 expression correlates significantly with clinical outcomes, genetic mutations, and immune cell infiltration.

Conclusions:

  • GPR65 serves as a prognostic indicator in cancer patients.
  • GPR65 possesses immunomodulatory functions and represents a potential target for cancer immunotherapy as a novel immune checkpoint.
Keywords:
GPR65Immune checkpointsImmune microenvironmentImmunotherapyTCGA

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