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Published on: April 28, 2020
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COVID-19-Associated Liver Injury
Daniel T Gildea1, Stephanie M Woo2, Corinne E O'Connor3
1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.
Hepatic Medicine : Evidence and Research
|February 28, 2023
Summary
This review examines liver injury from COVID-19 infection and treatments. It covers drug-induced liver injury, cholangiopathy, autoimmune hepatitis, and impacts on liver transplant recipients.
Area of Science:
- Hepatology
- Infectious Diseases
- Pharmacology
Background:
- COVID-19 (Coronavirus Disease 2019) can impact multiple organs, including the liver.
- Both the virus itself and its treatments have been associated with liver injury.
- Understanding these effects is crucial for patient management and treatment strategies.
Purpose of the Study:
- To comprehensively review the multifaceted effects of COVID-19 on liver health.
- To explore the potential contribution of drug-induced liver injury (DILI) to COVID-19-associated liver injury.
- To discuss significant liver-related outcomes and implications for liver transplant recipients.
Main Methods:
- Systematic review and analysis of existing literature and reported data.
- Examination of pathophysiological mechanisms underlying COVID-19 liver injury.
- Synthesis of evidence regarding DILI, COVID-19 cholangiopathy, and autoimmune hepatitis.
Main Results:
- COVID-19 infection and its treatments can lead to various forms of liver injury.
- Drug-induced liver injury is a potential cause of liver damage in COVID-19 patients.
- Other reported liver complications include COVID-19 cholangiopathy and autoimmune hepatitis.
Conclusions:
- COVID-19 poses significant risks to liver health, necessitating careful monitoring.
- DILI should be considered in the differential diagnosis of liver injury in COVID-19 patients.
- The implications for liver transplant recipients require specific attention and management protocols.
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