Copper and Palladium Cocatalyzed Defluorinative Coupling of gem-Difluoroalkenes and Acyl Chloride
Xinyu Liu1, Juanjuan Wu1, Chun Zhang1,2
1Institute of Molecular Plus, Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Weijin Rd. 92, Tianjin 300072, China.
Abstract:
A novel copper and palladium cocatalyzed defluorinative coupling of gem-difluoroalkenes and acyl chlorides has been developed. It is a practical method to prepare α-fluorochalcones, which are a kind of important unit in a variety of bioactive compounds. Under mild reaction conditions, a series of substrates with various functional groups could afford desired products smoothly. Further synthetic studies illustrated that the products of this chemistry could be used as versatile precursors to access complicated compounds. Furthermore, the reaction mechanism was proposed based on control experiments.
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