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Updated: Aug 8, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Metabolic switching of estrogen-related receptor alpha in breast cancer aggression
Madhulika Tripathi1, Brijesh Kumar Singh1
1Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore City, Singapore.
Abstract:
Orphan nuclear receptor estrogen-related receptor alpha (ERRα) is an important regulator of energy metabolism, whereas its hyperactivation in breast cancer has been shown to regulate cell migration, proliferation, and tumour development. These findings suggest a fine balance in the status of ERRα in regulating metabolic homeostasis or promoting cancer progression. In this issue, Brindisi et al. have shown that ERRα is endogenously activated by cholesterol and caused breast cancer aggressiveness. This study also supports the anti-tumour mechanisms of cholesterol-lowering drugs such as statins.
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