Copper iodide nanoparticles (CuI NPs): an efficient catalyst for the synthesis of alkynyl esters
Sushmita1,2, Monika Patel1, Deepika Thakur1
1Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India. averma@acbr.du.ac.in.
Abstract:
An environmentally benign protocol for the synthesis of alkynyl esters, by the cross-coupling of diazoacetate with various substituted alkynes under neat reaction conditions, has been described. Copper iodide nanoparticles (CuI NPs) were found to promote the Sonogashira-type coupling to afford the corresponding alkynyl esters in good yields. The CuI nanoparticles were characterized by PXRD, FESEM, EDAX, and Raman techniques. The developed methodology has several advantages such as a broad substrate scope, less reaction time, atom economy, avoidance of an additive/base/solvent, and enhanced values of green chemistry. The catalyst was recycled up to threefold without the loss of its catalytic activity.
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