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An injectable all-small-molecule dynamic metallogel for suppressing sepsis
Haotian Li1, Jianhua Zhang1, Hongrui Xue1
1College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China. ywli@scu.edu.cn.
Materials Horizons
|February 28, 2023
Summary
Researchers developed novel metallogels from small molecules, offering a new building block for dynamic hydrogels. These biocompatible materials show promise for tissue engineering and drug delivery with potent antibacterial properties.
Area of Science:
- Materials Science
- Biomedical Engineering
- Organic Chemistry
Background:
- All-small-molecule dynamic hydrogels are crucial for biomedical applications like cell culture and drug delivery.
- Limited availability of suitable building blocks restricts the development of new dynamic hydrogels.
- Metal-organic frameworks (MOFs) inspire new material design strategies.
Purpose of the Study:
- To develop a new class of all-small-molecule dynamic metallogels.
- To explore the use of aminoglycosides (AGs), 2,2'-bipyridine-4,4'-dicarboxaldehyde (BIPY), and metal ions as building blocks.
- To evaluate the properties and potential applications of the fabricated metallogels.
Main Methods:
- Facile fabrication of metallogels via direct gelation.
- Utilized coordination interactions and Schiff base reactions between AGs, BIPY, and metal ions.
- Characterized metallogels for biodegradability, biosafety, conductivity, mechanical properties, and antibacterial activity.
Main Results:
- Successfully synthesized novel metallogels using small molecular compounds.
- Demonstrated good biodegradability and biosafety of the metallogels.
- Exhibited excellent conductivity, tunable mechanical properties, and potent antibacterial activities in vitro and in vivo.
Conclusions:
- This study presents a new strategy for fabricating all-small-molecule dynamic metallogels.
- The developed metallogels offer a versatile platform for expanding the scope of dynamic hydrogels.
- These materials hold significant potential for diverse biomedical applications, including tissue engineering and therapeutics.
