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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Related Experiment Video

Updated: Aug 8, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells
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Exosome Mediated Cancer Therapeutic Approach:Present Status and Future Prospectives.

Anitha Roy1,2, Smiline Girija As3, Pitchaipillai Sankar Ganesh3

  • 1Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Velappanchavadi, PH Road, Chennai, Tamil Nadu, India.

Asian Pacific Journal of Cancer Prevention : APJCP
|February 28, 2023
PubMed
Summary

Extracellular vesicles (EVs), or exosomes, are key players in cancer, acting as biomarkers and drug delivery systems. This review explores their production, regulation, and therapeutic potential in cancer diagnostics and treatment.

Keywords:
cancer-therapeuticsdrug delivery vehiclesexosomesimmuno-therapy

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Extracellular vesicles (EVs), including exosomes, are secreted by cells and contain diverse biological molecules.
  • These vesicles have cell-independent functions, making them significant in various biological processes.
  • Exosomes are increasingly recognized for their roles in cancer progression, metastasis, and angiogenesis.

Approach:

  • This review synthesizes current knowledge on exosome biogenesis, regulation, and intercellular communication.
  • It examines the multifaceted roles of exosomes in cancer biology.
  • The review explores recent advancements in exosome-based cancer therapeutics and diagnostics.

Key Points:

  • Exosomes serve as vital biomarkers for cancer detection and monitoring.
  • They function as effective nanocarriers for targeted delivery of therapeutic agents like miRNA, siRNA, and anti-cancer drugs.
  • Exosomes possess theranostic potential, enabling combined diagnosis and therapy.
  • Their involvement in regulating tumor progression, metastasis, and angiogenesis is critical.

Conclusions:

  • Exosomes represent a promising frontier in cancer diagnostics and therapeutics.
  • Understanding exosome production and regulation is crucial for harnessing their clinical potential.
  • Further research into exosome applications could revolutionize cancer treatment strategies.