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COVID-19 Vaccination and Hospitalization Among Persons Living With Diagnosed HIV in New York State
Elizabeth M Rosenthal1,2,3, Wendy Patterson4, Joyce Chicoine4
1Center for Program Development, Implementation, Research and Evaluation, AIDS Institute, New York State Department of Health, Albany, NY.
Insights
COVID-19 vaccination reduces hospitalization for people with HIV (PLWDH), but disparities persist. Unvaccinated PLWDH, especially those of color, face higher risks, highlighting the need for equitable vaccine access.
Area of Science:
- Public Health
- Infectious Diseases
- Immunology
Background:
- Persons living with diagnosed HIV (PLWDH) experience higher COVID-19 diagnosis rates and worse outcomes.
- The impact of COVID-19 vaccination status on severe outcomes in PLWDH requires further investigation.
Purpose of the Study:
- To assess COVID-19 vaccination status and hospitalization risks among PLWDH in New York State.
- To compare these risks during the Delta and Omicron variants' predominance.
Main Methods:
- Matching HIV surveillance, immunization, and hospitalization databases.
- Comparing COVID-19 vaccination and hospitalization rates in PLWDH during Delta and Omicron variant periods.
Main Results:
- 68% of PLWDH were fully vaccinated or boosted by March 2022.
- Virally suppressed PLWDH were more likely to be vaccinated.
- Vaccination was protective, but hospitalization rate differences were smaller than in the general population.
Conclusions:
- 28% of PLWDH remained unvaccinated, double the rate in the general adult population.
- PLWDH of color, the unsuppressed, and those not in care were more likely to be unvaccinated, increasing disparities.
- Vaccination offered protection, yet disparities in COVID-19 outcomes persist among PLWDH.
Background:
Persons living with diagnosed HIV (PLWDH) have higher COVID-19 diagnoses rates and poorer COVID-19-related outcomes than persons living without diagnosed HIV. The intersection of COVID-19 vaccination status and likelihood of severe COVID-19 outcomes has not been fully investigated for PLWDH.
Setting:
New York State (NYS).
Methods:
We matched HIV surveillance, immunization, and hospitalization databases to compare COVID-19 vaccination and COVID-19-related hospitalizations among PLWDH during B.1.617.2 (Delta) and B.1.1.529 (Omicron) predominance.
Results:
Through March 4, 2022, 69,137 of the 101,205 (68%) PLWDH were fully vaccinated or boosted for COVID-19. PLWDH who were virally suppressed or in care were more often to be fully vaccinated or boosted compared with PLWDH who were not virally suppressed (77% vs. 44%) or without evidence of care (74% vs. 33%). Overall hospitalization rates were lower among virally suppressed PLWDH. During Delta predominance, PLWDH with any vaccination history who were in care had lower hospitalization rates compared with those not in care; during Omicron predominance, this was the case only for boosted PLWDH.
Conclusions:
Approximately 28% (28,255) of PLWDH in NYS remained unvaccinated for COVID-19, a rate roughly double of that observed in the overall adult NYS population. PLWDH of color were more often than non-Hispanic White persons to be unvaccinated, as were the virally unsuppressed and those without evidence of HIV-related care, threatening to expand existing disparities in COVID-19-related outcomes. Vaccination was protective against COVID-19-related hospitalizations for PLWDH; however, differences in hospitalization rates between fully vaccinated and unvaccinated PLWDH were smaller than those among all New Yorkers.
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