Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel pESI-encoded autotransporter adhesin PeaP of epidemic <i>Salmonella</i> strains mediates adhesion, atypical biofilm formation, and poultry colonization.

bioRxiv : the preprint server for biology·2026

Same author

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection.

Autophagy·2026

Same author

An exhaustive cell-based screen coupled with an intracellular-induced lux-based reporter identified bioactive molecules that inhibit host cell infection by intracellular pathogens.

Frontiers in cellular and infection microbiology·2026

Same author

Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions.

BioEssays : news and reviews in molecular, cellular and developmental biology·2025

Same author

Any1 is a phospholipid scramblase involved in endosome biogenesis.

The Journal of cell biology·2025

Same author

Destruction of the brush border by <i>Salmonella enterica</i> sv. Typhimurium subverts resorption by polarized epithelial cells.

Frontiers in microbiology·2024

Same journal

Neuronal membrane organization by the submembranous spectrin-ankyrin scaffold: evolution, specialization and disease.

Biological chemistry·2026

Same journal

Golgi-associated membrane scaffolds: roles in health and disease.

Biological chemistry·2026

Same journal

Mechanistic insights on spatiotemporal control of Ras-signaling.

Biological chemistry·2026

Same journal

Cysteine cathepsin proteases in apicomplexan parasites.

Biological chemistry·2026

Same journal

Electron donating and withdrawing groups affect the antioxidant activity of 4'-aminochalcones on gentamicin-induced kidney cell injury.

Biological chemistry·2026

Same journal

CNKSR2 scaffold function in the mammalian nervous system.

Biological chemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 8, 2025

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Published on: September 15, 2023

Setting up a data management infrastructure for bioimaging.

Susanne Kunis¹, Karen Bernhardt², Michael Hensel³

¹Department of Biology/Chemistry, Center of Cellular Nanoanalytics, Integrated Bioimaging Facility iBiOs, Osnabrück University, Babarastrasse 11, D-49076 Osnabrück, Germany.

Biological Chemistry

|February 28, 2023

Summary

This summary is machine-generated.

Implementing FAIR data principles for microscopy images is challenging. A new software tool, MDEmic, simplifies metadata collection, aiding researchers in managing complex bioimaging data and promoting data reusability.

Keywords:

FAIR OMERO metadata microscopy research data management

More Related Videos

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Related Experiment Videos

Last Updated: Aug 8, 2025

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Author Spotlight: Introducing the Tile/SED/Array Interface for Rapid Field of View Positioning in Tissue Imaging

Published on: September 15, 2023

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Area of Science:

Bioimaging
Data Science
Scientific Informatics

Background:

The Findable, Accessible, Interoperable, and Re-usable (FAIR) principles are crucial for modern science.
Microscopy image data present unique challenges in management due to volume, variety, and proprietary formats.
Effective metadata collection is essential for FAIR data but remains a significant hurdle for researchers.

Purpose of the Study:

To establish an infrastructure for centralized data management within an interdisciplinary research network.
To develop and integrate a flexible software tool (MDEmic) for efficient metadata processing of microscopy images.
To contribute to community efforts in defining metadata standards and reducing barriers in daily data management for bioimaging.

Main Methods:

Establishment of a Core Facility to provide centralized data management infrastructure.
Development and integration of the MDEmic software tool for metadata processing.
Engagement in community-wide efforts to define metadata standards and serialization formats.

Main Results:

Successful establishment of a research network infrastructure supporting centralized data management.
Development of MDEmic, a flexible tool simplifying metadata collection for microscopy images.
Initiation of community efforts to standardize metadata and interfaces for bioimaging data.

Conclusions:

Centralized data management and specialized tools like MDEmic can overcome challenges in implementing FAIR principles for microscopy data.
Standardization of metadata and interfaces is key to sustainable and successful bioimaging data management.
Interdisciplinary collaboration and dedicated infrastructure are vital for advancing scientific data sharing and reusability.