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Updated: Aug 8, 2025
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Efficacy of Multimodality Approach in Patients With Recurrent Head and Neck Squamous Cell Carcinoma
Pascale Alicia Hoell1, Khaled Elsayad2, Hendrik Berssenbruegge3
1Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
Background/Aim:
Head and neck squamous cell carcinoma (HNSCC) is characterized by high relapse rates and low survival in comparison to other malignancies.
Patients And Methods:
Fifty-two patients suffering from recurrent HNSCC were compared, analyzing the impact of different regimes, including surgery, radiotherapy (RT), chemotherapy and immunotherapy on progression-free survival (PFS), overall survival (OS), locoregional control (LRC), and adverse events.
Results:
The standard RT technique was intensity-modulated radiotherapy (IMRT) in all patients. In the multivariate analysis, higher cumulative RT dose significantly influenced LRC whereas surgery and age significantly impacted PFS and OS.
Conclusion:
IMRT dose-escalation, as well as surgery, appear beneficial in the treatment of recurrent HNSCC. Moreover, nivolumab and platin-based therapy might be superior agents for systemic therapy in comparison to cetuximab.
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