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Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial
Pilar Sanchis1,2,3, Paula Calvo4,5, Antelm Pujol6
1Laboratory of Renal Lithiasis Research, Department of Chemistry, University of Balearic Islands, Institute of Health Sciences Research [IUNICS- IdISBa], 07122, Palma of Mallorca, Spain. pilar.sanchis@uib.es.
Aim:
Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2.
Methods:
We performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period.
Results:
Patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta.
Conclusion:
This is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications.
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