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Related Experiment Videos

Ultrafiltration in diuretic-resistant cardiac failure.

I A Simpson1, K Simpson, A P Rae

  • 1University Department of Medical Cardiology, Royal Infirmary, Glasgow, Scotland.

Renal Failure
|January 1, 1987
PubMed
Summary

Ultrafiltration effectively treated fluid overload in patients with severe cardiac failure resistant to diuretics. This intervention led to significant fluid removal and sustained symptomatic improvement, enhancing diuretic response.

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Area of Science:

  • Cardiology
  • Nephrology
  • Critical Care Medicine

Background:

  • Cardiac failure often leads to diuretic resistance.
  • Peripheral edema is a distressing symptom in advanced cardiac failure.
  • Managing fluid overload in these patients is challenging.

Purpose of the Study:

  • To evaluate the efficacy of ultrafiltration in patients with diuretic-resistant cardiac failure.
  • To assess symptomatic improvement and fluid removal following ultrafiltration.
  • To determine the impact of ultrafiltration on subsequent diuretic response.

Main Methods:

  • Ultrafiltration was performed on 13 patients with diuretic-resistant cardiac failure and severe peripheral edema.
  • Fluid volume removed was recorded, ranging from 3.7 to 23 L (mean 11.8 L).

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  • Patient outcomes, including symptomatic improvement and response to diuretics, were monitored.

    • Main Results:

    • Ultrafiltration was successfully completed in 12 out of 13 patients.
    • All patients who underwent ultrafiltration experienced symptomatic improvement.
    • Significant fluid removal was achieved, with continued weight reduction post-procedure.
    • An improved response to diuretic therapy was observed in the week following ultrafiltration.

    Conclusions:

    • Ultrafiltration is a valuable therapeutic option for selected patients with diuretic-resistant cardiac failure.
    • It effectively manages fluid overload and alleviates distressing symptoms.
    • Ultrafiltration can improve the effectiveness of subsequent diuretic treatment.