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Updated: Aug 8, 2025

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
Published on: September 3, 2009
correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes
Emil Nyerki1,2, Tibor Kalmár1, Oszkár Schütz3
1Department of Pediatrics, University of Szeged Albert Szent-Györgyi Medical Center Faculty of Medicine, Szeged, Hungary.
Abstract:
Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×-11.9×) using samples with known family relations and known/unknown population structure. Based on our results, correctKin allows for the reliable identification of relatedness up to the 4th degree from variable/low-coverage ancient or badly degraded forensic whole genome sequencing data.
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