Related Experiment Video

Updated: Aug 8, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.4K

Therapeutic potential of CDK11 in cancer

Dalibor Blazek1

  • 1Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.

Clinical and Translational Medicine
|March 1, 2023
PubMed

Insights

Cyclin-dependent kinases (CDKs) regulate cell processes. A new study reveals CDK11

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Human cyclin-dependent kinases (CDKs) are crucial for cell cycle progression and transcription.
  • Deregulation of CDKs is common in tumors, making them attractive targets for cancer therapy.
  • CDK11 is essential for many malignancies, but its function and the mechanism of the inhibitor OTS964 were previously unknown.

Purpose of the Study:

  • To elucidate the primary cellular function of CDK11.
  • To understand the mode-of-action of the CDK11 inhibitor OTS964.
  • To explore the therapeutic potential of targeting CDK11 in cancer.

Main Methods:

  • The study investigated the role of CDK11 in cellular processes.
  • The mechanism of action of the compound OTS964 was examined.
  • Pre-mRNA splicing regulation by CDK11 was analyzed.

Main Results:

  • The inhibitor OTS964 was found to prevent spliceosome activation.
  • This finding reveals a critical role for CDK11 in regulating pre-mRNA splicing.
  • CDK11's function in splicing is now understood.

Conclusions:

  • CDK11 plays a key role in pre-mRNA splicing.
  • The findings provide insight into the mechanism of the anti-cancer compound OTS964.
  • Targeting CDK11 presents a promising therapeutic strategy for cancer treatment.
Keywords:
CDK11OTS964SF3B1cancerpladienolide Bspliceosomesplicing

More Related Videos

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

18.7K
A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers10:49

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

Published on: September 26, 2019

5.7K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.7K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.2K