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Related Experiment Video

Updated: Aug 8, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Allometric body shape indices, type 2 diabetes and kidney function: A two-sample Mendelian randomization study.

Alisa D Kjaergaard^1,2, Jesse Krakauer³, Nir Krakauer⁴

¹Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.

Diabetes, Obesity & Metabolism

|March 1, 2023

Summary

Body shape indices like ABSI and WHI are linked to higher kidney damage (UACR) in women, while HI is linked to lower UACR in both sexes. Type 2 diabetes risk is also associated with these body shape indices.

Keywords:

Mendelian randomization analysis albuminuria blood urea nitrogen chronic diabetes mellitus glomerular filtration rate kidney function tests obesity renal insufficiency type 2

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Area of Science:

Nephrology
Metabolic Health
Genetics

Background:

Body mass index (BMI) is a common measure of adiposity but doesn't fully capture body fat distribution.
Allometric body shape indices, independent of BMI, offer a more nuanced assessment of body composition.
Understanding the relationship between these indices and kidney function is crucial for public health.

Purpose of the Study:

To investigate the association between BMI-independent allometric body shape indices and kidney function.
To explore the potential mediating role of type 2 diabetes (T2D) in the relationship between body shape and kidney outcomes.

Main Methods:

Two-sample Mendelian randomization (MR) analysis using summary statistics from large biobanks (UK Biobank, CKDGen, DIAGRAM).
Examined A Body Shape Index (ABSI), Waist-Hip Index (WHI), and Hip Index (HI) against kidney function markers (UACR, eGFR, BUN).
Assessed T2D risk as a mediator for albuminuria and performed sensitivity analyses.

Main Results:

Genetically predicted higher ABSI and WHI were associated with increased urinary albumin-to-creatinine ratio (UACR) in women, but not men.
Genetically predicted higher HI was associated with decreased UACR in women and showed a similar trend in men.
Increased T2D risk was observed for genetically high ABSI and WHI in women, whereas genetically high HI decreased T2D risk in both sexes.

Conclusions:

Genetically determined Hip Index (HI) is associated with reduced risk of albuminuria, partly mediated by lower type 2 diabetes risk.
BMI-independent indices A Body Shape Index (ABSI) and Waist-Hip Index (WHI) show sex-specific associations with kidney function and T2D risk in women.